Second Quarterly Progress Report NO1-DC-9-2106 Effects of Remaining Hair Cells on Cochlear Implant Function

Auditory response to intracochlear electric stimuli following furosemide treatment.

The influence of functional hair cells on electrical stimulation of the auditory nerve is an important issue as individuals with significant residual hearing are now cochlear implant candidates. Previous work has shown that chemical deafening during the course of acute experiments changes the auditory nerve's responses to electrical stimulation [Third Quarterly Progress Report, NIH contract N01...

Effects of Remaining Hair Cells on Cochlear Implant Function

The Cochlear Implant

The studies on cochlear implants have been conducted in the United States, Austria, Brasil, France, Finland, and some other countries. Up to now, this technique does not seem to have a wide spread application. Indeed it can only apply cases of deafness still presenting sufficient neural remnants to transmit the message. Moreover, the patient must be totally deaf( quasi­ complete loss of har cel...

Evaluation of Saccular Function Pre-Post Cochlear Implant Surgery Using VEMPs

Objectives: The aim of present study was evaluation of saccule function in cochlear implant candidates with severe to profound sensory neural hearing loss Before and after cochlear implantation Methods: In this study 35 cochlear implant (CI) candidates with bilateral severe to profound sensory neural hearing loss before and about 30 days after cochlear implant and 20 normal-hearing cases as ...

Potential of Pluripotent Stem Cells for the Replacement of Inner Ears

The inner ear, which manages our senses of hearing and balance, has mechanosensitive hair cells, which convert vibration into electronic signal to depolarize auditory or vestibular neurons. Inner ear functions depend largely on hair cells, their associated neurons and cochlear lateral wall, and defects in these cells result in hearing loss and deafness. Although some investigations indicated ha...